Loving, caring, and always giving of itself. 

Cannabigerol (CBG) is considered the “mother of cannabinoids” because it is the first cannabinoid (in its acid form) produced in the hemp plant — and it’s always sacrificing its own wants and needs for the betterment of others. 

It’s the precursor to major cannabinoids you may be more familiar with like CBD (cannabidiol) and THC (tetrahydrocannabinol). Essentially, CBG evolves into other cannabinoids depending on the development and maturity of the cannabis plant. CBG is non-intoxicating and offers unique benefits, making it particularly promising, and is gaining traction in the skincare and wellness industries. 

This post explores the science behind CBG and its potential benefits for skin health.

What is CBG?

CBG is one of over 100 cannabinoids found in the cannabis plant. 

It originates as cannnabigerolic acid (CBGA), which, as mentioned above, is a precursor to CBD and THC. During the plant’s growth cycle, CBGA is converted into these compounds as the plant matures. Like any other living organism, the genetics of the plant play a crucial role in defining which cannabinoids will be most prevalent. 

Very few select plants are genetically predisposed to keep the majority of its CBG in that form, but it is important to harvest it early enough to limit formation of THCA and CBDA. CBGA must be decarboxylated — or activated typically through heat— to become CBG. 

Further research continues to promote CBG's topical benefits, leading to a rise in the popularity of hemp-derived skincare. With its unique versatility, CBG presents numerous and far-reaching benefits that extend beyond the capabilities of traditional cannabinoids. 

How Does CBG Work?

CBG interacts with the body’s endocannabinoid system (ECS), which regulates process like inflammation, pain, metabolism, hormones, skin health, and others. While it has a lower affinity for CB1 and CB2 receptors, CBG interacts with a range of receptors outside the ECS, including:

• TRPV1: Associated with pain and heat sensation.
• TRPA: Involved in cold and itch sensations.
• TRPM8: Linked to cold and menthol sensations.
• Alpha-2 adrenergic receptors: Helps regulate sympathetic nervous system. 

CBG’s diverse receptor activity contributes to its wide-ranging benefits.

5 Benefits of Natural Skincare with CBG

• CBG Anti-Inflammatory Properties

CBG is a potent anti-inflammatory agent, which makes it ideal for managing skin conditions like acne, eczema, and psoriasis. Research suggests that CBG can:

• Inhibit the production of inflammatory molecules.
• Reduce redness and irritation.

Studies have also shown that CBG can stimulate and desensitize TRPV1 channels, which play a role in inflammatory responses, providing relief for sensitive or inflamed skin.

• CBG for Overall Skin Health: Antibacterial and Anti-fungal Benefits

CBG has demonstrated significant antibacterial properties, including activity against methicillin-resistant Staphylococcus aureus (MRSA). This makes it valuable for preventing and treating skin infections, particularly those caused by bacteria or fungi.

• CBG for Acne: Sebum Regulation

Sebum plays a crucial role in keeping your skin and hair moisturized by forming a protective barrier that prevents water loss and helps protect against bacteria and environmental damage. CBG’s ability to balance sebum production in sebaceous glands can help manage acne-prone skin. While excessive sebum leads to clogged pores and breakouts, a well-regulated production ensures a healthy skin barrier without excessive oiliness.

• CBG for Anti-Aging: Antioxidant Protection

CBG’s antioxidant properties help neutralize free radicals, which are responsible for premature aging. By reducing oxidative stress, CBG can:

• Prevent wrinkles and fine lines.
• Enhance skin elasticity.
• Promote an even skin tone.

• CBG for Sensitive Skin: Moisturization and Skin Barrier Support

Emerging evidence suggests that CBG may improve skin hydration by reducing inflammation and supporting the skin’s natural barrier. This is especially beneficial for aging or dry skin, where maintaining moisture levels is critical.

Market Trends and Applications

The skincare market is beginning to embrace CBG as a hero ingredient. By focusing on CBG’s anti-inflammatory, antimicrobial, and antioxidant properties, companies can create more transparent marketing strategies and educate consumers on why this cannabinoid deserves attention.

How to Maximize CBG’s Benefits

For optimal results, CBG can be formulated with complementary ingredients. For example:

• CBD: Enhances the anti-inflammatory and antioxidant effects through the entourage effect, which is the calling-card for cannabinoid skincare. 
• Delta-9 THC: Though legal limitations exist; it may enhance receptor binding when used in trace amounts.
• Moisturizers and oils: Ingredients like jojoba oil or shea butter can amplify CBG’s hydrating effects.

What are the advantages of CBG? 

While CBD and THC are more commonly used in skin products, CBG offers distinct advantages:

• CBD: Primarily known for its calming and anti-inflammatory properties.
• THC: Offers localized pain relief but is often restricted due to legal concerns.
• CBG: Combines anti-inflammatory, antibacterial, and sebum-regulating effects, making it a versatile option for various skin concerns. CBG’s reach beyond the ECS to other physiological systems also opens the doors to more benefits.

Conclusion

Cannabigerol (CBG) is an emerging powerhouse in the skincare industry, offering a range of benefits for inflammation, acne, aging, and skin barrier support. With its non-intoxicating profile and multifaceted therapeutic properties, CBG has the potential to revolutionize topical products and redefine the role of cannabinoids in skincare. As research continues to uncover its capabilities, consumers and formulators alike should keep an eye on this promising compound.

References

• Anti-microbial effects: PubMed
• Neuroprotectant properties: NCBI Article
• Pain and anti-inflammatory properties: NCBI Article
• GABA uptake inhibition: PubMed
• Anti-cancer potential: PubMed
• Skin cannabinoid receptors: Molecules Journal
• CBG in dry-skin syndrome and acne: Wiley Online Library
• Comprehensive pathways and therapeutic review: Journal of Pharmacology and Experimental Therapeutics
• Cannabinoids and acne: PubMed